I used to use Advantage18 which kills only adult fleas, and is a pestiside. It is from the vet, available without a vet vist/checkup. Then I found a better option, available with a checkup, for my cats:
Q: What is Revolution® (selamectin)?
A: Revolution is the first-ever FDA-approved, topically applied medication for cats that:
- Kills adult fleas (Ctenocephalides felis) and prevents flea eggs from hatching.
- Prevents heartworm disease caused by Dirofilaria immitis.
- Treats and controls ear mites (Otodectes cynotis).
- Treats and controls roundworms (Toxocara cati) and hookworms (Ancylostoma tubaeforme).
Q: How does Revolution® (selamectin) work?
A: Revolution enters the bloodstream through the skin. Concentrations of Revolution in the blood and tissues prevent heartworm disease and prevent and treat roundworm and hookworm infections. Revolution selectively redistributes from the blood to the skin and other tissues, where it provides protection against fleas, flea eggs, and ear mites.
Q: What are the most common side effects?
Revolution is generally well-tolerated. In studies, less than 1% of cats and dogs experienced digestive upset. Approximately 1% of cats experienced temporary hair loss at the application site. Do not use in sick, weak or underweight animals. See U.S. Prescribing Information for more details.
Above from https://www.revolution4cats.com/default.aspx?sec=Product%20Overview
Flea/Tick Products - FAQ's
How long does it take to kill all fleas after first application on an animal that has fleas?
Revolution: 42 hours to zero fleas counted
Advantage: 24 hours to zero fleas counted
Frontline & Frontline Plus: 42 hours to zero fleas counted (24 hours to spread all over animal’s body and 18 hours to kill the fleas)
Does it kill ticks as well as fleas?
Revolution: Yes, but because this product is licensed as a drug and not as an insecticide, it can only make label claims against the species of tick it was tested for. There is no reason to think other tick species would not be sensitive. The species it was tested against is Dermacentor variabilis.
Advantage: No, there is no tick activity at all. This product is highly specific for fleas.
Frontline & Frontline Plus: Yes, this product was tested specifically against four tick species: the deer tick, the lone star tick, the American dog tick, and the brown dog tick.
Activity against parasites other than fleas and ticks?
Revolution: Yes, product is active against ear mites, sarcoptic mange mites in dogs, roundworms and hookworms in cats.
Advantage: Fleas only
Frontline & Frontline Plus: Fleas and ticks only
How long does a single application last?
Revolution: one month
Advantage: one month
Frontline & Frontline Plus: one month for ticks, one month for fleas in the cat, 1 to 3 months for fleas in the dog
How soon after bathing can it be applied?
Revolution: As soon as the pet is dry
Advantage: As soon as the pet is dry
Frontline & Frontline Plus: Manufacturer recommends waiting 2 days after bathing before applying. The product can be applied sooner but will take longer to spread over the body if there is inadequate oil on the skin as would be the case just after a bath.
Does it wash off?
Revolution: No - this product is an endectocide, which means it is absorbed internally and spreads throughout the body including back to the skin. Because it acts internally it cannot be washed off.
Advantage: Yes - this product will be washed off completely with a degreasing shampoo. It can withstand one bath between applications and swimming once a week between applications but no more
Frontline & Frontline Plus: No - this product remains topical but is stored in the oil secreting glands of the skin. If the pet gets wet, the skin layer of product can be washed off but will be replaced as the oil producing glands re-secrete it.
Flea killing active ingredient:
Frontline & Frontline Plus: Fipronil; Frontline Plus: Fipronil plus Methoprene (methoprene is a long acting steralizer of fleas)
How young can the pet be for application?
Revolution: Puppies - 6 weeks, kittens - 6 weeks
Advantage: Puppies - 7 weeks, kittens - 8 weeks
Frontline & Frontline Plus: Puppies -10 weeks, kittens -12 weeks (Frontline Plus not currently approved for dogs under 11 pounds - approval expected later)
Approved for use in pregnant or nursing mother dogs/cats?
Advantage: not in this country but in other countries yes (U.S. EPA does not recognize testing done for other countries and testing in pregnancy/lactation has not been done in the U.S.)
Frontline & Frontline Plus: no
Does the pet need a veterinarian office call in the last year to get the product?
Revolution: Yes, this is a prescription drug.
Advantage: No, this is an insecticide, not a drug, but the manufacturer sells its product for resale only through veterinarians so that proper usage etc. can be explained.
Frontline & Frontline Plus: No, this is an insecticide, not a drug, but the manufacturer sells its product for resale only through veterinarians so that proper usage etc. can be explained.
Is the product safe for use on sick, elderly or debilitated patients?
Revolution: Manufacturer specifically cautions against such use.
Advantage: Product should be safe for such use provided the patient is receiving veterinary care. Otherwise, if the pet is inactive or hospitalized in a cage, the product may not spread around the body as rapidly as usual.
Frontline & Frontline Plus: Product should be safe for such use provided the patient is receiving veterinary care otherwise. If the pet is inactive or hospitalized in a cage, the product may not spread around the body as rapidly as usual.
Revolution: Comes in a 6-pack (3-pack for puppies / kittens).
Advantage: Comes in a 4-pack or a 6-pack.
Frontline & Frontline Plus: Comes in a 3-pack or a 6-pack.
Link to manufacturer's web site:
Frontline & Frontline Plus: www.frontline.com